Decreased plasma and cerebrospinal fluid glutamine concentrations in a patient with bialaphos poisoning-Reference-Cited by-同舟云学术

Decreased plasma and cerebrospinal fluid glutamine concentrations in a patient with bialaphos poisoning

Published:2001-08 Issue:8 Volume:20 Page:429-434
ISSN:0960-3271
Container-title:Human & Experimental Toxicology
language:en
Short-container-title:Hum Exp Toxicol

Author:

Ohtake T¹,Yasuda H²,Takahashi H³,Goto T²,Suzuki K⁴,Yonemura K⁵,Hishida A²

Affiliation:

1. Department of Medicine, Fujinomiya City General Hospital, 3-1, Nishiki-cho Fujinomiya 418-0076, Japan

2. First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

3. Department of Neurosurgery, Fujinomiya City General Hospital, Fujinomiya, Japan

4. Second Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

5. Hemodialysis Unit, Hamamatsu University School of Medicine, Hamamatsu, Japan

Abstract

A 47-year-old Japanese woman undergoing maintenance hemodialysis (HD) was admitted to our hospital because of poisoning with the herbicide bialaphos. Respiratory arrest and loss of consciousness ensued rapidly, accompanied by convulsions and nystagmus. Treatment with HD and direct hemoperfusion, followed by HD alone, effectively removed bialaphos and its chief toxic metabolite (L-AMPB) from the circulation (bialaphos decreased from 0.33 to <0.05 g/ml andL-AMPBfrom14to0.86 g/ml). The glutamate concentration improved gradually after the removal of bialaphos and L-AMPB from plasma (plasma glutamate concentration: 250.4 nmol/l on day 5 to 120.6 nmol/l on day 26). Decreased glutamine concentration in cerebrospinal fluidwasdemonstratedforthefirsttimeaswellasinplasma, indicating glutaminesynthetase inhibition notonlyinplants but also in humans by bialaphos poisoning.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1191/096032701682692973

Reference29 articles.

1. Development of a New Herbicide, Bialaphos

2. Overview of herbicide mechanisms of action.

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