FEATURES OF THE EFFECT OF VARIOUS FORMS OF VITAMIN D ON THE BONE AND JOINT SYSTEM

Abstract

Vitamin D takes part into the metabolism of the bone tissue, regulating the processes of mineralization and remodeling. There are a lot of data on uses of using of vitamin D in patients of trauma and orthopedic profile, but opinions about the method of taking, dosage, effectiveness differ greatly and requires more in-depth research.The objectiveof this study was to review and analyze of actual clinical and experimental researches related to the influence of metabolites of vitamin D in the endoprosthesis of large joints, among the available sources of medical database of PubMed, Cohraine, e-Library.The results of most studies of local and systemic use of metabolites of vitamin D led to the conclusion about the beneficial effects of these compounds on bone regeneration in traumatology and orthopedics. However, further researches are required to clearly identify the clinical application of these approaches.We supposed that the following factors considered for long-term work: assessment of long-term effect and usage of standardized doses, learning new derivatives of vitamin D, synergy in the combinations of vitamin D preparations, pharmacokinetics of vitamin D preparations and polymorphisms of genes associated with vitamin D, genes influencing the life activity of bone and assessment of the effect of concomitant disease, systemic pathological processes on related of vitamin D metabolism, and bone restoration. We are also define the simultaneous corrections of vitamin D levels as an important component of the compensation of bone disorders in trauma and orthopedic patients.