Synthesis and Biological Evaluation of Sulfamoyl Carboxamide Derivatives from Sulfur-containing α-Amino acids
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Published:2022-07-29
Issue:4
Volume:49
Page:
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ISSN:0125-2526
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Container-title:Chiang Mai Journal of Science
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language:
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Short-container-title:CMJS
Author:
Egbujor Melford C., ,Okoro Uchechukwu C.,Egu Attah S.,Okonkwo Vivian, I.,Okafor Sunday N.,Emeruwa Chigbundu N.,Egwuatu Pius I.,Umeh Odera R.,Eziafakaego Mercy I.,Amasiatu Ifeanyi S.,Nwobodo David C., , , , , , , , , ,
Abstract
acids and sulfonyl chloride. The characterization of the compounds was done using FTIR, 1H-NMR, 13C-NMR, and elemental analysis. Their antioxidant, antimalarial, antimicrobial activities and molecular docking were evaluated. Compounds 5h (MIC, 0.3, 0.5, 0.3 and 0.4 mg/mL) was the most potent antibacterial agent against Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Salmonella typhi, compounds 5a (MIC, 0.7 mg/mL) and 5g (MIC, 0.7m g/mL) were most potent against Pseudomonas aeruginosa while compound 5e (MIC, 0.5 and 0.8 mg/mL) had the best in vitro antifungal activity against Aspergillus niger and Candida albicans. Compound 5d (1C50 = 1.128 μg/mL) displayed an antioxidant activity comparable with ascorbic acid (1C50 = 1.000 μg/mL) and compound 5e (4, 14, 4%) effected the most signifi cant reduction in the percentage malaria parasitaemia comparable with artemeter lumefantrin (5, 4, 4%) after 5 days of treatment of the mice. From the molecular docking results, compound 5c had a strong molecular interaction with the appropriate drug target, Escherichia coli DNA gyrase complexed with 1-ethyl-3-[8-methyl-5-(2-methyl-pyridin-4-yl) isoquinolin-3-yl]urea (PDB code: 5MMN). The title compounds displayed signifi cant antimicrobial, antioxidant and antimalarial activities.
Publisher
Chiang Mai University
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Materials Science,General Mathematics,General Chemistry
Cited by
2 articles.
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