Nowadays, there is a growing use of plasma technology, especially in medicine and aesthetics. Plasma medicine is an innovative, multidisciplinary science combining plasma physics and technology with medicine and life sciences. Billions of dollars are spent annually in the United States to rejuvenate and reduce signs of aging. For this reason, several methods have been created to perform such operations. Methods with different degrees of invasiveness, from cosmetic surgery, like forehead lifts and blepharoplasty, to noninvasive, such as high-intensity focused ultrasound and nonablative lasers, have been used in the field of aesthetics and skin rejuvenation. Plasma can also be used as a noninvasive, minimally invasive, or even invasive method in cosmetic applications such as removing wrinkles and strengthening the skin, that can somewhat replace cosmetic procedures such as blepharoplasty and rhytidectomy. By using various active species, plasma affects biological activities and increases the proliferation and transfer of skin cells. With local application of heat and an increase in proliferation and activity of fibroblasts, the production of type III collagen and elastin density in the skin increases. Plasma can be used to sublimate the skin and remove excess tissue. This article summarizes the most recent studies and clinical trials in dermatology and skin rejuvenation, in which different cold plasma sources (jet and spark) have been used, and examines their results.