Efficacy and Nuances of Precision Molecular Engineering for Hodgkinâs Disease to a Gene Therapeutic Approach-Reference-Cited by-同舟云学术

Efficacy and Nuances of Precision Molecular Engineering for Hodgkinâs Disease to a Gene Therapeutic Approach

Published:2024 Issue:5 Volume:44 Page:41-50
ISSN:1040-8401
Container-title:Critical Reviews in Immunology
language:en
Short-container-title:Crit Rev Immunol

Author:

Qadir Muhammad Imran,Ahmed Bilal,Hussain Nadir

Abstract

Gene therapy is a particularly useful treatment for nervous system genetic diseases, including those induced especially by infectious organisms and antigens, and is being utilized to treat Hodgkin's disease (HD). Due to the possible clonal relationship between both disorders, immunotherapy directed against CD20 positive cells may be a more effective treatment in patients with persistent HD and NHL. HL growth can be inhibited both <i>in vitro</i> and <i>in vivo</i> by AdsIL-13Ralpha2. High-dose treatment combined with stem cell transplantation has been effective in treating HIV-negative lymphoma that has progressed to high-risk or relapsed disease. For therapy, LMP2-specific CTL will be used. Furthermore, it is possible to view the cytotoxicity of genetically modified adenoviruses that express proteins such as p27Kip1, p21Waf1, and p16INK4A as a foundational element for (2,5)-derived ALCL genetic treatment for Hodgkin's disease.

Publisher

Begell House

Link

https://www.dl.begellhouse.com/download/article/2807bd835f430e2f/CRI-52378.pdf

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