The protective effect of rutin supplement in Azithromycin-induced thyroid gland gland toxicity in male albino rats

Abstract

The current study was conducted in the animals house / Department of biology / Al- University of Qadisiyah from November to February This is for the purpose of studying the effect of rutin to reducing the potential effects of azithromycin on functional of thyroid gland in albino rats    This examination aim to research the defensive ability of flavonoid Rutin against Azithromycin incited thyroid gland injury in experimental rats. 40 male albino rats , were divided in four groups: first group (G1) control , was given distiller water orally. The second group (G2) , was treated as a dose of (30) mg/kg of azithromycin for 10 days , third group (G3) was treated as a dose of (50) mg/kg of rutin for 10 days , and the fourth (G4) was treated as a dose of (30) mg/kg of azithromycin and (50) mg/kg of rutin for 10 days.    Results, indicated that caused a significantly decline (P<0.05) T3 , T4 and Thyroid Stimulating Hormone (TSH ) levels in plasma of G2 compared with G1,  The results also showed a significant increase in (MDA)and decrease in the level of (SOD) in a group2 (G2) Compared with the control group,while the level of T3 , T4 , TSH, MDA and SOD was normal in (G3) and (G4) , this results proved that used rutin to lessen damage effects of by reduction of generating ROS and ameliorate thyroid toxicity in rats , by restoring normal hormones levels .      The histological study: also showed that pathological histological changes occurred in (G2),  represented by changing in diameter of the thyroid gland's follicles there were smaller irregular thyroid follicles, an increase in the thickness of the lining layer of the vesicles and the occurrence of hyperplasia , and colloids as well as bubbles in the colloidal substance.