Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR-Reference-Cited by-同舟云学术

Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR

Published:2015-10-19 Issue:5 Volume:7 Page:5240-5257
ISSN:1949-2553
Container-title:Oncotarget
language:en
Short-container-title:Oncotarget

Author:

Verbrugge Sue Ellen¹²,Al Marjon¹,Assaraf Yehuda G.³,Kammerer Sarah¹⁴⁵,Chandrupatla Durga M.S.H.¹⁴,Honeywell Richard⁴,Musters Rene P.J.⁶,Giovannetti Elisa⁴,O’Toole Tom⁷,Scheffer George L.⁸,Krige David⁹¹⁰,de Gruijl Tanja D.⁴,Niessen Hans W.M.⁸,Lems Willem F.¹,Kramer Pieternella A.¹¹,Scheper Rik J.⁸,Cloos Jacqueline¹²,Ossenkoppele Gert J.¹³,Peters Godefridus J.⁴,Jansen Gerrit¹

Affiliation:

1. Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, VU University Medical Center, Amsterdam, The Netherlands

2. Present address: Department of Clinical Chemistry, UMCU, Utrecht, The Netherlands

3. The Fred Wyszkowsky Cancer Research Laboratory, Faculty of Biology, The Technion-Israel Institute of Technology, Haifa, Israel

4. Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands

5. Present address: Institute of Biophysics, Medical University of Graz, Graz, Austria

6. Department of Physiology, VU University, Amsterdam, The Netherlands

7. Department of Molecular Cell Biology, VU University, Amsterdam, The Netherlands

8. Departments of Pathology and Cardiac Surgery, ICaR-VU, VU University Medical Center, Amsterdam, The Netherlands

9. Chroma Therapeutics Ltd, Abingdon, United Kingdom

10. Present address: Immunocore Ltd, Oxford, UK

11. Isala Hospital, Zwolle, The Netherlands

12. Department of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands

13. Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands

Publisher

Impact Journals, LLC

Subject

Oncology

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