VTT-006, an anti-mitotic compound, binds to the Ndc80 complex and suppresses cancer cell growth in vitro-Reference-Cited by-同舟云学术

VTT-006, an anti-mitotic compound, binds to the Ndc80 complex and suppresses cancer cell growth in vitro

Published:2021-12-10 Issue: Volume:8 Page:134-153
ISSN:2331-4737
Container-title:Oncoscience
language:en
Short-container-title:Oncoscience

Author:

Laine Leena J.¹²,Mäki-Jouppila Jenni H.E.¹²³⁴,Kutvonen Emma¹²,Tiikkainen Pekka¹,Nyholm Thomas K.M.⁵,Tien Jerry F.⁶,Umbreit Neil T.⁶,Härmä Ville¹,Kallio Lila¹,Davis Trisha N.⁶,Asbury Charles L.⁷,Poso Antti⁸,Gorbsky Gary J.⁹,Kallio Marko J.¹²

Affiliation:

1. VTT Health, VTT Technical Research Centre of Finland Ltd., Otaniemi, Finland

2. Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku 20520, Finland

3. Drug Research Doctoral Programme, University of Turku, Finland

4. Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland

5. Department of Biosciences, Åbo Akademi University, Turku, Finland

6. Department of Biochemistry, University of Washington, Seattle, WA, USA

7. Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA

8. School of Pharmacy, University of Eastern Finland, Kuopio, Finland

9. Cell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA

Publisher

Impact Journals, LLC

Subject

Cancer Research,Oncology

Reference65 articles.

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4. Cheeseman IM, Chappie JS, Wilson-Kubalek EM, Desai A. The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell. 2006; 127:983–97. https://doi.org/10.1016/j.cell.2006.09.039. PMID:17129783

5. McCleland ML, Kallio MJ, Barrett-Wilt GA, Kestner CA, Shabanowitz J, Hunt DF, Gorbsky GJ, Stukenberg PT. The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. Curr Biol. 2004; 14:131–37. https://doi.org/10.1016/j.cub.2003.12.058. PMID:14738735

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