Phylogenetic Analysis of Wesselsbron Virus Isolated from Field-Captured Mosquitoes during a Rift Valley Fever Outbreak in Kabale District, Uganda

Phylogenetic Analysis of Wesselsbron Virus Isolated from Field-Captured Mosquitoes during a Rift Valley Fever Outbreak in Kabale District, Uganda—2016

Published:2023-01-11 Issue:1 Volume:108 Page:161-164
ISSN:0002-9637
Container-title:The American Journal of Tropical Medicine and Hygiene
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Author:

Kayiwa John T.¹,Mayanja Martin N.¹,Nakayiki Teddy Muwawu¹,Senfuka Fred¹,Mugga Julius¹,Koehler Jeffrey W.²,Mossel Eric C.³,Lutwama Julius J.¹

Affiliation:

1. Department of Arbovirology, Emerging, and Re-emerging Diseases, Uganda Virus Research Institute, Entebbe, Uganda;

2. U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland;

3. Division of Vector-Borne Diseases, U.S. Centers for Disease Control and Prevention, Fort Collins, Colorado

Abstract

ABSTRACT. After confirmation of two human cases of Rift Valley fever (RVF) in March 2016 in the Kabale district of Uganda, an entomological investigation was conducted with a focus on mosquito species composition and abundance of known and potential mosquito vector species, and virus testing to identify species most likely involved in Rift Valley fever virus transmission. This information could be used to forecast risk and facilitate improvement of prevention and response tools for use in preventing or controlling future outbreaks. From these collections, two virus isolates were obtained, one each from a pool of Aedes tricholabis and Ae. gibbinsi. Next-generation sequencing identified both isolates as Wesselsbron virus, family Flaviviridae, a neglected arbovirus of economic importance. These are the first reported Wesselsbron virus isolates from Uganda since 1966.

Publisher

American Society of Tropical Medicine and Hygiene

Subject

Virology,Infectious Diseases,Parasitology

Link

https://www.ajtmh.org/downloadpdf/journals/tpmd/108/1/article-p161.xml

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