Long-term Persistence of Opisthorchis viverrini Antigen in Urine: A Prospective Study in Northeast Thailand-Reference-Cited by-同舟云学术

Long-term Persistence of Opisthorchis viverrini Antigen in Urine: A Prospective Study in Northeast Thailand

Published:2023-02-01 Issue:2 Volume:108 Page:356-358
ISSN:0002-9637
Container-title:The American Journal of Tropical Medicine and Hygiene
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Author:

Worasith Chanika¹²,Wongphutorn Phattharaphon²³,Kopolrat Kulthida Y.⁴,Homwong Chutima²,Techasen Anchalee²⁵,Thanan Raynoo⁶,Wangboon Chompunoot⁷,Eamudomkarn Chatanun¹²,Sithithaworn Jiraporn⁵,Crellen Thomas⁸⁹,Sithithaworn Paiboon¹²

Affiliation:

1. Department of Parasitology, Faculty of Medicine, Khon Kaen University, Thailand;

2. Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand;

3. Biomedical Science Program, Graduate School, Khon Kaen University, Khon Kaen, Thailand;

4. Faculty of Public Health, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon, Thailand;

5. Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand;

6. Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;

7. School of Preclinical Science, Institute of Science, Suranaree University of Technology, Nakhon Rachasima, Thailand;

8. School of Biodiversity, One Health and Veterinary Medicine, Glasgow, United Kingdom;

9. Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

Abstract

ABSTRACT. Antigen detected in urine for the diagnosis of opisthorchiasis has a low daily variation; however, the longer term variability in antigen concentrations is unknown. In this study, we prospectively monitored Opisthorchis viverrini antigen concentrations for 30 consecutive days and at subsequent monthly intervals in a cohort of opisthorchiasis-positive individuals. On the basis of the monoclonal antibody–based ELISA, the profiles of antigen-positive rate and antigen concentration exhibited no significant change over 30 days with a mean proportion positive of 87.1% (range 73.7%–100%), and the average antigen concentration was 29.7 ± 2.2 ng/mL (mean ± SE). The urine antigen concentration at baseline was similar to the subsequent measurements at 2, 4, 6, and 10 months in the follow-up study (P > 0.05). The consistency and low daily and long-term fluctuation of O. viverrini antigen in urine demonstrates the reliability of urine assay for diagnosis of opisthorchiasis.

Publisher

American Society of Tropical Medicine and Hygiene

Subject

Virology,Infectious Diseases,Parasitology

Link

https://www.ajtmh.org/downloadpdf/journals/tpmd/108/2/article-p356.xml

Reference11 articles.

1. The current status of opisthorchiasis and clonorchiasis in the Mekong Basin,2012

2. Current status of human liver fluke infections in the Greater Mekong Subregion,2021

3. Towards evidence-based control of Opisthorchis viverrini.,2021

4. Current perspectives on opisthorchiasis control and cholangiocarcinoma detection in Southeast Asia,2018

5. Repeated stool sampling and use of multiple techniques enhance the sensitivity of helminth diagnosis: a cross-sectional survey in southern Lao People’s Democratic Republic,2015

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