Accelerating Clinical Evaluation of Repurposed Combination Therapies for COVID-19

Author:

Rayner Craig R.12,Dron Louis34,Park Jay J. H.53,Decloedt Eric H.6,Cotton Mark F.7,Niranjan Vis8,Smith Patrick F.1,Dodds Michael G.1,Brown Fran1,Reis Gilmar9,Wesche David1,Mills Edward J.34

Affiliation:

1. Certara, Princeton, New Jersey;

2. Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia;

3. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada;

4. Cytel Inc., Vancouver, Canada;

5. Department of Medicine, Experimental Medicine, University of British Columbia, Vancouver, Canada;

6. Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;

7. Family Clinical Research Unit, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;

8. RxMD, Chennai, India;

9. PUC Minas Medical School of Medicine at Contagem, Belo Horizonte, Brazil

Publisher

American Society of Tropical Medicine and Hygiene

Subject

Virology,Infectious Diseases,Parasitology

Reference16 articles.

1. A real-time dashboard of clinical trials for COVID-19;Thorlund;Lancet Digit Health,2020

2. Rapid repurposing of drugs for COVID-19;Guy;Science,2020

3. Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing;Riva;Nature,2020

4. Model-informed drug repurposing: viral kinetic modelling to prioritize rational drug combinations for COVID-19;Dodds;Br J Clin Pharmacol,2020

5. Dexamethasone in hospitalized patients with COVID-19—preliminary report;Horby;N Engl J Med,2020

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