Case Report: Management of Acanthamoeba Rhinosinusitis in a Patient with Chronic Lymphocytic Leukemia-Reference-Cited by-同舟云学术

Case Report: Management of Acanthamoeba Rhinosinusitis in a Patient with Chronic Lymphocytic Leukemia

Published:2024-07-03 Issue:1 Volume:111 Page:48-50
ISSN:0002-9637
Container-title:The American Journal of Tropical Medicine and Hygiene
language:
Short-container-title:

Author:

Di Valerio Elizabeth¹,Justice Jeb M.²,Gushiken Alexis C.³⁴

Affiliation:

1. University of Florida College of Medicine, Gainesville, Florida;

2. Division of Rhinology and Skull Base Surgery, Department of Otolaryngology, University of Florida College of Medicine, Gainesville, Florida;

3. Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida;

4. Section of Infectious Diseases, North Florida/South Georgia Veterans Health System, Gainesville, Florida

Abstract

ABSTRACT. Infections caused by free-living amoebae pose a significant public health threat owing to growing populations of immunocompromised hosts combined with diagnostic delays, treatment difficulties, and high case fatality rates. Nasopharyngeal infections caused by Acanthamoeba are rare and the optimal treatment is not well established. We report a case of Acanthamoeba rhinosinusitis in a patient with chronic lymphocytic leukemia who presented with headaches and chronic rhinosinusitis refractory to multiple courses of antibiotics. A diagnosis of Acanthamoeba rhinosinusitis was established through broad-range polymerase chain reaction testing on sinus tissue. The patient had a favorable response to treatment, which included surgical debridement, cessation of immunosuppressants, and a three-drug regimen consisting of miltefosine, fluconazole, and sulfadiazine.

Publisher

American Society of Tropical Medicine and Hygiene

Link

https://www.ajtmh.org/downloadpdf/journals/tpmd/111/1/article-p48.xml

Reference10 articles.

1. Pathogenic free-living amoebae: Epidemiology and clinical review;Trabelsi,2012

2. The epidemiology and clinical features of non-keratitis Acanthamoeba infections in the United States, 1956–2020;Haston,2023

3. Diseases of the nose and pnasal sinuses in the human immunodeficiency virus-infected population;Tami,1992

4. An unusual source of sinonasal disease in an immunocompromised patient: A case report of the clinical presentation, diagnosis, and treatment of Acanthamoeba rhinosinusitis;Guirguis,2022

5. Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae;Rice,2020