Case Report: Late Reactivation of Herpes B Virus After a Monkey Bite: A Case of Severe Meningoencephalitis-Reference-Cited by-同舟云学术

Case Report: Late Reactivation of Herpes B Virus After a Monkey Bite: A Case of Severe Meningoencephalitis

Published:2023-12-06 Issue:6 Volume:109 Page:1277-1281
ISSN:0002-9637
Container-title:The American Journal of Tropical Medicine and Hygiene
language:
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Author:

Ponzetto Ester¹,Delhez Quentin¹,Hoppenbrouwers Maarten²,De Schryver Nicolas¹,Serck Nicolas¹,Dugernier Thierry¹,Duray Marie-Céline³,Gressens Benjamin¹,Vinetti Marco¹,Sips Gregorius J.²⁴,van Kampen Jeroen²,GeurtsvanKessel Corine H.²,van Boheemen Sander²

Affiliation:

1. Intensive Care Unit, Clinique Saint-Pierre, Ottignies, Belgium;

2. Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands;

3. Department of Neurology, Clinique Saint-Pierre, Ottignies, Belgium;

4. Public Health Service Rotterdam-Rijnmond, Rotterdam, The Netherlands

Abstract

ABSTRACT. Macacine alphaherpesvirus 1, also known as herpes B virus (BV), is an alphaherpesvirus endemic to several macaque species, capable of causing zoonotic infections in humans, with high mortality rates. Evidence of reactivation in humans has rarely been reported. Here we depict a case of BV reactivation after 54 years, leading to severe meningoencephalitis. This case supports the use of antiviral prophylaxis in patients surviving a confirmed BV central nervous system infection. We sequenced DNA from BV obtained from the patient’s cerebrospinal fluid. Phylogenetic analysis showed significant divergence in the clustering of this particular BV strain compared with other known BVs. Therefore, additional efforts are needed to obtain a broader sequence landscape from BVs circulating in monkeys.

Publisher

American Society of Tropical Medicine and Hygiene

Subject

Virology,Infectious Diseases,Parasitology

Link

https://www.ajtmh.org/downloadpdf/journals/tpmd/109/6/article-p1277.xml

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