Characterization of Weissella Species during a 3-Year Observational Study – An Emerging Threat

Author:

Jamwal Ashima1,Varghese Gerlin1,Sarawat Deepika1,Tejan Nidhi1,Patel Sangram Singh1,Sahu Chinmoy1

Affiliation:

1. Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

Abstract

ABSTRACT. Weissella species are mistaken for Lactobacillus or Leuconostoc because of their Gram-staining property and resistance to vancomycin. In this study, we aimed to evaluate the demographic pattern, presenting symptoms, risk factors, associated pathologies, and clinical outcomes in patients with Weissella infection. We also analyzed the antibiotic susceptibility pattern of the Weissella species isolated. This retrospective observational study was done from January 2021 to August 2023 in a tertiary care referral center in Uttar Pradesh. All Weissella species isolated from blood cultures or cerebrospinal fluid (CSF) samples during this period were included in the study. Twenty-four–hour growth from a positive blood culture or CSF sample was identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Demographic and clinical details of the patients were extracted from the hospital information system. Kirby-Bauer disk diffusion was used for antibiotic susceptibility testing. During the 3-year study, 13 isolates of Weissella species were identified in our laboratory. Among the patients, male predominance was seen. The age range of the patients was 5–53 years. The samples were blood samples (n = 11) and CSF samples (n = 2). Of these isolates, 12 (92.3%) were identified as Weissella confusa and 1 (7.69%) was identified as Weissella viridescens. Common risk factors were anemia, prolonged hospital stay, indwelling catheter, chemotherapy, and chronic kidney disease. All the isolates in this study were sensitive to amikacin, daptomycin, amoxicillin-clavulanate, minocycline, and linezolid. Death was attributed to Weissella infection in three patients. Weissella species are opportunistic organisms that need to be identified quickly and precisely to guarantee the right course of treatment.

Publisher

American Society of Tropical Medicine and Hygiene

Reference19 articles.

1. Severe infective endocarditis of native valves caused by Weissella confusa detected incidentally on echocardiography;Shin,2007

2. Weissella confusa bacteremia in an immune-competent patient with underlying intramural hematomas of the aorta;Lee,2013

3. The genus Weissella: Taxonomy, ecology and biotechnological potential;Fusco,2015

4. Identification and significance of Weissella species infections;Kamboj,2015

5. The Weissella genus: Clinically treatable bacteria with antimicrobial/probiotic effects on inflammation and cancer;Ahmed,2022

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