Cross Talk between MicroRNAs and Dengue Virus

Author:

Macha Nur Omar1,Komarasamy Thamil Vaani1,Harun Sarahani2,Adnan Nur Amelia Azreen1,Hassan Sharifah Syed1,Balasubramaniam Vinod R. M. T.1

Affiliation:

1. Infection and Immunity Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor, Malaysia;

2. Institute of Systems Biology Malaysia, National University of Malaysia, Selangor, Malaysia

Abstract

ABSTRACT. Dengue fever (DF) is an endemic infectious tropical disease and is rapidly becoming a global problem. Dengue fever is caused by one of the four dengue virus (DENV) serotypes and is spread by the female Aedes mosquito. Clinical manifestations of DF may range from asymptomatic to life-threatening severe illness with conditions of hemorrhagic fever and shock. Early and precise diagnosis is vital to avoid mortality from DF. A different approach is required to combat DF because of the challenges with the vaccines currently available, which are nonspecific; each is capable of causing cross-reaction and disease-enhancing antibody responses against the residual serotypes. MicroRNAs (miRNAs) are known to be implicated in DENV infection and are postulated to be involved in most of the host responses. Thus, they might be a suitable target for new strategies against the disease. The involvement of miRNAs in cellular activities and pathways during viral infections has been explored under numerous conditions. Interestingly, miRNAs have also been shown to be involved in viral replication. In this review, we summarize the role of known miRNAs, specifically the role of miRNA Let-7c (miR-Let-7c), miR-133a, miR-30e, and miR-146a, in the regulation of DENV replication and their possible effects on the initial immune reaction.

Publisher

American Society of Tropical Medicine and Hygiene

Reference127 articles.

1. Economic and disease burden of dengue in Southeast Asia;Shepard,2013

2. The global distribution and burden of dengue;Bhatt,2013

3. Host molecules regulating neural invasion of Zika virus and drug repurposing strategy;Tan,2022

4. Finding a chink in the armor: Update, limitations, and challenges toward successful antivirals against flaviviruses;Komarasamy,2022

5. Zika virus targets human STAT2 to inhibit type I interferon signaling;Grant,2016

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