Retrospective Review of Blood Culture-Confirmed Cases of Enteric Fever in Navi Mumbai, India: 2014

Retrospective Review of Blood Culture-Confirmed Cases of Enteric Fever in Navi Mumbai, India: 2014–2018

Published:2023-09-06 Issue:3 Volume:109 Page:571-574
ISSN:0002-9637
Container-title:The American Journal of Tropical Medicine and Hygiene
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Author:

Jayaprasad Niniya¹,Borhade Priyanka¹,LeBoa Christopher²,Date Kashmira³,Joshi Shrikrishna⁴,Shimpi Rahul¹,Andrews Jason R.²,Luby Stephen P.²,Hoffman Seth A.²

Affiliation:

1. National Public Health Surveillance Project, World Health Organization–Country Office for India, New Delhi, India;

2. Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California;

3. Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia;

4. Dr. Joshi’s Central Clinical Microbiology Laboratory, Navi Mumbai, India

Abstract

ABSTRACT. India has one of the highest estimated burdens of enteric fever globally. Prior to the implementation of Typbar-TCV typhoid conjugate vaccine (TCV) in a public sector pediatric immunization campaign in Navi Mumbai, India, we conducted a retrospective review of blood culture-confirmed cases of typhoid and paratyphoid fevers to estimate the local burden of disease. This review included all blood cultures processed at a central microbiology laboratory, serving multiple hospitals, in Navi Mumbai (January 2014–May 2018) that tested positive for either Salmonella Typhi or Salmonella Paratyphi A. Of 40,670 blood cultures analyzed, 1,309 (3.2%) were positive for S. Typhi (1,201 [92%]) or S. Paratyphi A (108 [8%]). Culture positivity was highest in the last months of the dry season (April–June). Our findings indicate a substantial burden of enteric fever in Navi Mumbai and support the importance of TCV immunization campaigns and improved water, sanitation, and hygiene.

Publisher

American Society of Tropical Medicine and Hygiene

Subject

Virology,Infectious Diseases,Parasitology

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