Optimized Quantification of Naproxen Based on DPV and a Multiwalled MWCNT-Carbon Paste Electrode

Abstract

This work describes the development of a novel methodology for the voltammetric quantification of naproxen using a carbon paste electrode modified with multi-walled carbon nanotubes (MWCNT-CPE). By cyclic voltammetry (CV), the electrochemical behavior of naproxen on the MWCNT-CPE was studied, where its oxidation resulted to be a non-reversible and diffusion-controlled process. Naproxen quantification was carried out using differential pulse voltammetry (DPV), the statistical analysis of the results lead to a LOD and LOQ for the proposed methodology of 0.1 ± 0.03 and 0.33 μmol l−1, respectively. The interference study was performed considering different chemical species, only diclofenac interfered with the analytical response since it oxidizes at a potential very close to that of naproxen. The proposed methodology was applied for the determination of naproxen in commercial tablets (simple and compound) obtaining very favorable results as compared with the official techniques for naproxen analysis.