Progress in Signaling Pathways Associated to Irritable Bowel Syndrome

Abstract

Irritable bowel syndrome (IBS) is the most common chronic functional bowel disease with abdominal pain and diarrhea as the main symptoms. Its course develops repeatedly, which seriously affects the quality of life of patients. At present, it occupies a large amount of medical resources, but its onset and etiology is not completely clear. It is currently believed that visceral hypersensitivity, brain-gut axis and gastrointestinal motility abnormalities are their important pathophysiology bases. In recent years, recent studies show that the signaling pathways in viscera and brain-gut axis, such as 5-HT, NF- κb, topv 1 and MAPK, have important effects on IBS. It can repair intestinal inflammation, reduce visceral sensitivity, enhance intestinal mucosal barrier and regulate intestinal power through the regulation of these series of signaling pathways, and plays an important role in multi-level, multi-link and multi-target treatment of IBS. Based on the signal pathway, this paper summarizes the research progress of IBS signal pathway in recent years, in order to provide theoretical support and diagnosis and treatment ideas for the clinical treatment of TCM in IBS.