Electrophysiological and pharmacological characterization of a novel and potent neuronal Kv7 channel opener SCR2682 for antiepilepsy-Reference-Cited by-同舟云学术

Electrophysiological and pharmacological characterization of a novel and potent neuronal Kv7 channel opener SCR2682 for antiepilepsy

Published:2019-05-07 Issue:8 Volume:33 Page:9154-9166
ISSN:0892-6638
Container-title:The FASEB Journal
language:en
Short-container-title:FASEB j.

Author:

Zhang Fan¹,Liu Yani²,Tang Feng³,Liang Bo⁴,Chen Huanming⁴,Zhang Hailin¹,Wang Kewei²⁵⁶

Affiliation:

1. The Key Laboratory of Neural and Vascular Biology Ministry of Education The Key Laboratory of New Drug Pharmacology and Toxicology, Hebei Province Department of Pharmacology Hebei Medical University Shijiazhuang China

2. Department of Pharmacology Qingdao University Qingdao China

3. Medicinal Chemistry, Simcere Pharmaceutical Nanjing China

4. Medicinal Chemistry Shanghai Zhimeng BioPharma Shanghai China

5. Institute of Innovative Drugs School of Pharmacy Qingdao University Qingdao China

6. Center for Brain Science and Brain‐Inspired Intelligence Guangzhou China

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Natural Science Foundation of Shandong Province

Guangdong Science and Technology Department

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.201802848RR

Reference52 articles.

1. Anxiolytic Effects of Maxipost (BMS-204352) and Retigabine via Activation of Neuronal Kv7 Channels

2. Effects of Retigabine on the Neurodegeneration and Extracellular Glutamate Changes Induced by 4-Aminopyridine in Rat Hippocampus In Vivo

3. (S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: An Orally Bioavailable KCNQ2 Opener with Significant Activity in a Cortical Spreading Depression Model of Migraine

4. Bimodal effects of the Kv 7 channel activator retigabine on vascular K+ currents

5. KCNQ potassium channels: physiology, pathophysiology, and pharmacology

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