Cell‐penetrating anti‐GFAP VHH and corresponding fluorescent fusion protein VHH‐GFP spontaneously cross the blood‐brain barrier and specifically recognize astrocytes: application to brain imaging-Reference-Cited by-同舟云学术

Cell‐penetrating anti‐GFAP VHH and corresponding fluorescent fusion protein VHH‐GFP spontaneously cross the blood‐brain barrier and specifically recognize astrocytes: application to brain imaging

Published:2012-06-22 Issue:10 Volume:26 Page:3969-3979
ISSN:0892-6638
Container-title:The FASEB Journal
language:en
Short-container-title:FASEB j.

Author:

Li Tengfei¹,Bourgeois Jean‐Pierre²,Celli Susanna³,Glacial Fabienne⁴⁵⁶,Le Sourd Anne‐Marie²,Mecheri Salah⁷,Weksler Babette⁸,Romero Ignacio⁹,Couraud Pierre‐Olivier⁴⁵⁶,Rougeon François¹⁰,Lafaye Pierre¹

Affiliation:

1. Platform: Production de Protéines Recombinantes et d'Anticorps‐ProteopoleInstitut PasteurParisFrance

2. Unité Genes, Synapses, et CognitionCentre National de la Recherche Scientifique (CNRS) Unité de Recherche Associée (URA) 2182Institut PasteurParisFrance

3. Unité de Dynamique des Réponses ImmunesInstitut National de la Santé et de la Recherche Médicale (INSERM), U668Institut PasteurParisFrance

4. INSERM, U1016Institut CochinParisFrance

5. CNRSUnité Mixte de Recherche (UMR) 8104ParisFrance

6. Université Paris DescartesParisFrance

7. Unité de Biologie des Interactions Hôte‐ParasitesCNRS U2581Institut PasteurParisFrance

8. Division of Hematology‐OncologyWeill Cornell Medical CollegeNew YorkNew YorkUSA

9. Department of Life SciencesThe Open UniversityMilton KeynesUK

10. Unité de Génétique et Biochimie du DéveloppementInstitut PasteurParisFrance

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.11-201384

Reference45 articles.

1. Blood-brain barrier transport of cationized immunoglobulin G: enhanced delivery compared to native protein.

2. Enhanced cellular uptake and in vivo biodistribution of a monoclonal antibody following cationization

3. Ultracytochemical characterization of anionic sites in the wall of brain capillaries

4. Delivery of peptides and proteins through the blood–brain barrier

5. Intracellular antibodies (intrabodies) as research reagents and therapeutic molecules for gene therapy

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