A Sos‐derived peptidimer blocks the Ras signaling pathway by binding both Grb2 SH3 domains and displays antiproliferative activity
Author:
Affiliation:
1. Département de Pharmacochimie Moléculaire et StructuraleINSERM U266‐CNRS UMR 8600UFR des Sciences Pharmaceutiques et Biologiques 75270 Paris Cedex 06 France
2. INSERM U248Institut CURIE 75248 Paris Cedex 05 France
Publisher
Wiley
Subject
Genetics,Molecular Biology,Biochemistry,Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1096/fasebj.13.1.31
Reference64 articles.
1. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
2. The Grb2 adaptor
3. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
4. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
5. Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2
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