Suppression of Fas‐FasL‐induced endothelial cell apoptosis prevents diabetic blood‐retinal barrier breakdown in a model of streptozotocin‐induced diabetes

Author:

Joussen Antonia M.123,Poulaki Vassiliki13,Mitsiades Nicholas4,Cai Wen‐yi5,Suzuma Izumi5,Pak John5,Ju Shyr‐Te5,Rook Susan L.5,Esser Peter2,Mitsiades Constantin4,Kirchhof Bernd2,Adamis Anthony P.136,Paul Aiello Lloyd56

Affiliation:

1. Retina Research InstituteMassachusetts Eye and Ear Infirmary, Harvard Medical School 234 Charles Street Boston MA 02114 USA

2. Department of Vitreoretinal SurgeryCenter for Ophthalmology and Center for Molecular Medicine (ZMMK), University of Köln Joseph Stelzmann Str. 9 D‐50931 Köln Germany

3. Surgical Research LaboratoriesChildren's Hospital, Harvard Medical School Boston MA 02115 USA

4. Dana‐Farber Cancer InstituteHarvard Medical School Boston MA 02115 USA

5. Beetham Eye InstituteJoslin Diabetes Center Boston MA 02115 USA

6. Department of OphthalmologyHarvard Medical School Boston MA 02115 USA

Funder

Deutsche Forschungsgemeinschaft

Juvenile Diabetes Research Foundation International

Ernst und Berta Grimmke Stiftung

Falk Foundation

National Institutes of Health

Foundation Fighting Blindness

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Reference29 articles.

1. Visual Impairment in Diabetes

2. Prevention of leukostasis and vascular leakage in streptozotocin‐induced diabetic retinopathy via intercellular adhesion molecule‐1 inhibition;Miyamoto K.;Proc. Natl. Acad. Sci. USA,1999

3. Vascular Endothelial Growth Factor (VEGF)-Induced Retinal Vascular Permeability Is Mediated by Intercellular Adhesion Molecule-1 (ICAM-1)

4. Enhanced expression of intracellular adhesion molecule‐1 and P‐selectin in the diabetic human retina and choroid;McLeod D. S.;Am. J. Pathol,1995

5. Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy;Schröder S.;Am. J. Pathol,1991

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