Up‐regulation of the mammalian target of rapamycin complex 1 subunit Raptor by aldosterone induces abnormal pulmonary artery smooth muscle cell survival patterns to promote pulmonary arterial hypertension

Author:

Aghamohammadzadeh Reza1,Zhang Ying‐Yi1,Stephens Thomas E.1,Arons Elena1,Zaman Paula1,Polach Kevin J.2,Matar Majed2,Yung Lai‐Ming1,Yu Paul B.1,Bowman Frederick P.1,Opotowsky Alexander R.13,Waxman Aaron B.4,Loscalzo Joseph1,Leopold Jane A.1,Maron Bradley A.15

Affiliation:

1. Department of MedicineDivision of Cardiovascular MedicineBrigham and Women's HospitalBostonMassachusettsUSA

2. Celsion CorporationLawrencevilleNew JerseyUSA

3. Department of CardiologyBoston Children's HospitalBostonMassachusettsUSA

4. Department of MedicineDivision of Pulmonary and Critical Care MedicineBrigham and Women's HospitalBostonMassachusettsUSA

5. Department of CardiologyBoston Veterans Affairs Healthcare SystemBostonMassachusettsUSA

Funder

British Heart Foundation

National Institutes of Health

National Heart, Lung, and Blood Institute

American Heart Association

Pulmonary Hypertension Association

Dunlevie Family Fund for Adult Congenital Heart Disease

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

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