Targeting <scp>SARS‐CoV</scp> ‐2 by synthetic dual‐acting thiol compounds that inhibit Spike/ <scp>ACE2</scp> interaction and viral protein production-Reference-Cited by-同舟云学术

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Targeting SARS‐CoV ‐2 by synthetic dual‐acting thiol compounds that inhibit Spike/ ACE2 interaction and viral protein production

Published:2022-12-30 Issue:2 Volume:37 Page:
ISSN:0892-6638
Container-title:The FASEB Journal
language:en
Short-container-title:The FASEB Journal

Author:

Fraternale Alessandra¹^ORCID,De Angelis Marta²,De Santis Riccardo³,Amatore Donatella³,Masini Sofia¹,Monittola Francesca¹,Menotta Michele¹,Biancucci Federica¹,Bartoccini Francesca¹,Retini Michele¹,Fiori Valentina⁴,Fioravanti Raoul⁵,Magurano Fabio⁵^ORCID,Chiarantini Laura¹,Lista Florigio³,Piersanti Giovanni¹,Palamara Anna T.²⁵,Nencioni Lucia²^ORCID,Magnani Mauro¹,Crinelli Rita¹

Affiliation:

1. Department of Biomolecular Sciences University of Urbino Carlo Bo Urbino Italy

2. Department of Public Health and Infectious Diseases Laboratory Affiliated to Istituto Pasteur Italia‐Fondazione Cenci Bolognetti, Sapienza University of Rome Rome Italy

3. Scientific Department Army Medical Center Rome Italy

4. DIATHEVA SRL Cartoceto Italy

5. Department of Infectious Disease Istituto Superiore di Sanità Rome Italy

Funder

Ministero dell'Università e della Ricerca

Sapienza Università di Roma

Università degli Studi di Urbino Carlo Bo

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.202201157RR

Reference45 articles.

1. Impact of Thiol–Disulfide Balance on the Binding of Covid-19 Spike Protein with Angiotensin-Converting Enzyme 2 Receptor

2. The age-dependent decline of the extracellular thiol-disulfide balance and its role in SARS-CoV-2 infection

3. Exploring antiviral and anti-inflammatory effects of thiol drugs in COVID-19

4. Disruption of disulfides within RBD of SARS‐CoV‐2 spike protein prevents fusion and represents a target for viral entry inhibition by registered drugs

5. Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein

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3. A synthetic thiol molecule releasing N-acetyl-l-cysteine and cysteamine drives early up-regulation of immunoproteasome subunits in the lymph nodes of mice infected with LP-BM5 leukemia retrovirus;Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease;2024-01

4. Inhibition of myeloid-derived suppressor cell (MDSC) activity by redox-modulating agents restores T and B cell proliferative responses in murine AIDS;International Immunopharmacology;2023-11

5. The influence of redox modulation on hypoxic endothelial cell metabolic and proteomic profiles through a small thiol‐based compound tuning glutathione and thioredoxin systems;BioFactors;2023-07-06

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