Bone marrow osteoprogenitors are depleted whereas osteoblasts are expanded independent of the osteogenic vasculature in response to zoledronic acid
Author:
Affiliation:
1. Department of Oncology and MetabolismExperimental Cancer Medicine Centre
2. Department of Physics and Astronomy
3. School of Clinical DentistryUniversity of SheffieldSheffieldUnited Kingdom
Funder
Cancer Research UK
Engineering and Physical Sciences Research Council
Publisher
Wiley
Subject
Genetics,Molecular Biology,Biochemistry,Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.201900553RR
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1. Zoledronic Acid Has Differential Antitumor Activity in the Pre- and Postmenopausal Bone Microenvironment In Vivo
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5. Nitrogen-Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including Ras
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