Biological age as a predictor of life expectancy in patients with ischemic heart disease

Abstract

The work aimed to elucidate the relationship between the rate of ageing, determined by the criterion of biological age (BA), and the life expectancy of coronary heart disease (IHD) patients. We analyzed 220 case histories of IHD patients aged 40–80 years. The cause of death in patients was IHD. During the observation period, patients were determined anthropometric parameters, BP, ECG, complete blood count, ESR, fasting blood glucose, lipid metabolism, urea, creatinine and prothrombin index. The calculated BA formula was obtained on a group of 110 healthy people aged 40 to 80 years. Using stepwise multiple regression, the most informative indicators were selected and an equation was obtained linking the age of people with these indicators (r=0.671; p<0.0001). Using this formula, the BA of IHD patients and the rate of ageing of each person were calculated as the difference between their BA and chronological age. The data obtained analysis made it possible to establish a significant relationship between the rate of ageing and life expectancy in patients with IHD (r=-0.368; p<0.0001). Keywords: biological age; life expectancy IHD.