The role of acute phase inflammatory proteins in the pathogenesis of Metabolic syndrome in obese horses-Reference-Cited by-同舟云学术

The role of acute phase inflammatory proteins in the pathogenesis of Metabolic syndrome in obese horses

Published:2024-03-28 Issue:1 Volume:10 Page:3-6
ISSN:2411-0388
Container-title:Journal for Veterinary Medicine, Biotechnology and Biosafety
language:en
Short-container-title:J. Vet. Med. Biotechnol. Biosafety

Author:

Borovkov S. B.¹^ORCID,Boiko V. S.¹^ORCID

Affiliation:

1. National Scientific Center ‘Institute of Experimental and Clinical Veterinary Medicine’, Kharkiv, Ukraine

Abstract

Metabolic syndrome and obesity in horses are closely related processes that are accompanied by chronic inflammation. Our research aimed to establish the normative indicators of acute phase inflammation proteins in obese horses. We conducted a study on twenty horses, ten of which were in the control group and ten were in the experimental group, showing signs of obesity. The Henneke scoring system was used to assess the body condition. This system ranks animals from one to nine, with one being exhausted and nine being very fat. Serum concentrations of circulating immune complexes, seromucoids, C-reactive protein, haptoglobin, total protein, and its fractions were determined. It was found that significant changes in protein metabolism occur in animals with obesity, namely: the content of circulating immune complexes, seromucoids, C-reactive protein, haptoglobin, and globulins significantly increase, indicating the development of inflammatory processes in horses due to obesity. The localization of these processes is associated both with obesity in animals and possibly with laminitis, the development of which is one of the pathogenetic links of metabolic syndrome

Publisher

Kharkiv Entomological Society

Reference22 articles.

1. Bilous, L. L. and Kovalchuk, N. A. (2015) ‘Immune status different lines of Russian Trotting horses’ [Imunnyi status konei rosiiskoi rysystoi porody riznykh linii], The Animal Biology [Biolohiia tvaryn ], 17(4), pp. 162. Available at: http://nbuv.gov.ua/UJRN/bitv_2015_17_4_28. [in Ukrainian].

2. Carter, R. A., McCutcheon, L. J., Valle, E., Meilahn, E. N. and Geor, R. J. (2010) ‘Effects of exercise training on adiposity, insulin sensitivity, and plasma hormone and lipid concentrations in overweight or obese, insulin-resistant horses’, American Journal of Veterinary Research, 71(3), pp. 314–321. doi: 10.2460/ajvr.71.3.314.

3. CE (The Council of Europe). (1986) European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes. (European Treaty Series, No. 123). Strasbourg: The Council of Europe. Available at: https://conventions.coe.int/treaty/en/treaties/html/123.htm.

4. CEC (The Council of the European Communities) (2010) ‘Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes’, The Official Journal of the European Communities, L 276, pp. 33–79. Available at: http://data.europa.eu/eli/dir/2010/63/oj.

5. Durham, A. E., Frank, N., McGowan, C. M., Menzies‐Gow, N. J., Roelfsema, E., Vervuert, I., Feige, K. and Fey, K. (2019) ‘ECEIM consensus statement on Equine metabolic syndrome’, Journal of Veterinary Internal Medicine, 33(2), pp. 335–349. doi: 10.1111/jvim.15423.