Author:
Masthan KMK,Saggu Tajinder Kaur,Dudanakar Mahesh Pundaleek,Nisa Shams UI
Abstract
ABSTRACT
Background
Cigarette smoke contains various oxygen-free radicals which are considered as the main causes of damage to biomolecules when exposed to cigarette smoke. Saliva is the first biological fluid that encounters inhaled cigarette smoke (CS) and has an antioxidant defense system able to counter toxic activities of free radical species. So, the aim of this study was to compare the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in saliva of smokers and nonsmokers.
Materials and methods
Unstimulated saliva of 200 males (100 smokers and 100 nonsmokers) was collected. The saliva was centrifuged and the activity of salivary superoxide dismutase and glutathione peroxidase was measured according to a specific assay.
Results
The mean value of superoxide dismutase activity was significantly higher in the smoking group than in the nonsmoker group, while the levels of GSH-Px activity was significantly higher in the nonsmoking group than in the smoking group.
Conclusion
Cigarette smoke leads to an alteration in salivary antioxidant activity. Evaluating the variations in the level of antioxidant enzymes (SOD and GSH-Px) in smoker's saliva might be useful for estimating the level of oxidative stress caused by cigarette smoke. Thus, it may help in patient's education regarding the ill-effects of smoking and determining the evolution and progress of various oral diseases.
How to cite this article
Saggu TK, Masthan KMK, Dudanakar MP, Nisa SUI, Patil S. Evaluation of Salivary Antioxidant Enzymes among Smokers and Nonsmokers. World J Dent 2012;3(1):18-21.
Publisher
Jaypee Brothers Medical Publishing
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献