Comparison Of Outcome And Side Effects Profile Of Treatment Of Overactive Bladder With Different Classes Of Drugs

Abstract

Objective: Overactive bladder (OAB) is a common condition characterized by urinary urgency, frequency, and incontinence. Anticholinergics, beta-3 agonists, and mirabegron are commonly used to manage OAB symptoms. Anticholinergics are effective but may cause side effects such as dry mouth, constipation, and drowsiness. Beta-3 agonists, like Mirabegron, are a viable option for individuals seeking to avoid these side effects. Methods: A study of 45 female patients with OAB symptoms was conducted to evaluate the effectiveness of two cross-over protocols. Group A received mirabegron followed by solifenacin, and group B received mirabegron followed by solifenacin. Results: The results showed that both treatments were effective in reducing the symptoms of OAB as measured by the IPSS, OABSS, and VAS scores for emergency and distention. The side effects of dry mouth and constipation were relatively mild. However, a p-value of 0.007 shows that there was no significant difference in effectiveness and side effects between the two groups. Conclusion: Both treatment options can be effective for OAB, but each has specific disadvantages. Consulting with a healthcare provider is important to determine the best treatment option based on an individual's specific needs and medical history. Keywords: Overactive bladder, Solifenacin, Mirabegron, Anticholinergics.