WNT Inhibition and Increased FGF Signaling Promotes Derivation of Less Heterogeneous Primed Human Embryonic Stem Cells, Compatible with Differentiation

Author:

Taelman Jasin1,Popovic Mina1,Bialecka Monika2,Tilleman Laurentijn3,Warrier Sharat1,Van Der Jeught Margot1,Menten Björn4,Deforce Dieter3,De Sutter Petra1,Van Nieuwerburgh Filip3,Abe Kuniya5,Heindryckx Björn1,Chuva de Sousa Lopes Susana M.12

Affiliation:

1. Ghent-Fertility and Stem Cell Team (G-FaST), Department for Reproductive Medicine, Ghent University Hospital, Ghent, Belgium.

2. Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands.

3. Laboratory of Pharmaceutical Biotechnology, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.

4. Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.

5. Technology and Development Team for Mammalian Genome Dynamics, RIKEN BioResource Center, Tsukuba, Japan.

Publisher

Mary Ann Liebert Inc

Subject

Cell Biology,Developmental Biology,Hematology

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