Efficient Inhibition of Human Telomerase Reverse Transcriptase Expression by RNA Interference Sensitizes Cancer Cells to Ionizing Radiation and Chemotherapy-Reference-Cited by-同舟云学术

Efficient Inhibition of Human Telomerase Reverse Transcriptase Expression by RNA Interference Sensitizes Cancer Cells to Ionizing Radiation and Chemotherapy

Published:2005-07 Issue:7 Volume:16 Page:859-868
ISSN:1043-0342
Container-title:Human Gene Therapy
language:en
Short-container-title:Human Gene Therapy

Author:

Nakamura Mitsuhiro¹,Masutomi Kenkichi²,Kyo Satoru¹,Hashimoto Manabu¹,Maida Yoshiko¹,Kanaya Taro¹,Tanaka Masaaki¹,Hahn William C.²,Inoue Masaki¹

Affiliation:

1. Department of Obstetrics and Gynecology, Graduate School of Kanazawa University, Kanazawa, Ishikawa 920-8641, Japan.

2. Department of Medical Oncology, Dana-Farber Cancer Institute and Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/hum.2005.16.859

Reference39 articles.

1. Telomerase overexpression in K562 leukemia cells protects against apoptosis by serum deprivation and double-stranded DNA break inducing agents, but not against DNA synthesis inhibitors

2. The length of telomeric G-rich strand 3'-overhang measured by oligonucleotide ligation assay

3. Telomerase inhibition, oligonucleotides, and clinical trials

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