Structure of a Thyrotropin Receptor Monoclonal Antibody Variable Region Provides Insight into Potential Mechanisms for its Inverse Agonist Activity-Reference-Cited by-同舟云学术

Structure of a Thyrotropin Receptor Monoclonal Antibody Variable Region Provides Insight into Potential Mechanisms for its Inverse Agonist Activity

Published:2018-07 Issue:7 Volume:28 Page:933-940
ISSN:1050-7256
Container-title:Thyroid
language:en
Short-container-title:Thyroid

Author:

Chen Chun-Rong¹,McLachlan Sandra M.¹,Hubbard Paul A.²,McNally Randall²,Murali Ramachandran²,Rapoport Basil¹

Affiliation:

1. Thyroid Autoimmune Disease Unit, Department of Medicine, Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angeles, California.

2. Department of Biomedical Sciences, Research Division of Immunology, Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angeles, California.

Publisher

Mary Ann Liebert Inc

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

Link

https://www.liebertpub.com/doi/pdf/10.1089/thy.2018.0176

Reference51 articles.

1. The Thyrotropin (TSH)-Releasing Hormone Receptor: Interaction with TSH and Autoantibodies

2. A molecular dissection of the glycoprotein hormone receptors

3. The thyrotropin receptor and the regulation of thyrocyte function and growth

4. In Chinese Hamster Ovary K1 Cells Dog and Human Thyrotropin Receptors Activate Both the Cyclic AMP and the Phosphatidylinositol 4,5-Bisphosphate Cascades in the Presence of Thyrotropin and the Cyclic AMP Cascade in Its Absence

5. The Extracellular Domain Suppresses Constitutive Activity of the Transmembrane Domain of the Human TSH Receptor: Implications for Hormone-Receptor Interaction and Antagonist Design

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery and design of G protein-coupled receptor targeting antibodies;Expert Opinion on Drug Discovery;2023-03-29

2. Mutations in G Protein–Coupled Receptors: Mechanisms, Pathophysiology and Potential Therapeutic Approaches;Pharmacological Reviews;2020-11-20