Detection of Inducible Replication-Competent HIV-1 Subtype C Provirus Despite Long-Term Antiretroviral Treatment in Perinatally Infected Adolescents in Botswana-Reference-Cited by-同舟云学术

Detection of Inducible Replication-Competent HIV-1 Subtype C Provirus Despite Long-Term Antiretroviral Treatment in Perinatally Infected Adolescents in Botswana

Published:2021-01-01 Issue:1 Volume:37 Page:16-23
ISSN:0889-2229
Container-title:AIDS Research and Human Retroviruses
language:en
Short-container-title:AIDS Research and Human Retroviruses

Author:

Koofhethile Catherine K.¹²,Moyo Sikhulile¹²,Kotokwe Kenanao P.¹,Chang Charlotte²,Mokgethi Patrick¹,Muchoba Lorato¹,Mokgweetsi Selebogo¹,Makhema Joseph¹²,Lockman Shahin¹²,Gaseitsiwe Simani¹²,de Oliveira Tulio³⁴,Essex M.¹²,Shapiro Roger¹²,Kanki Phyllis²,Novitsky Vladimir¹²

Affiliation:

1. Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.

2. Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

3. College of Health Sciences, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal (UKZN), Durban, South Africa.

4. KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), UKZN, Durban, South Africa.

Publisher

Mary Ann Liebert Inc

Subject

Infectious Diseases,Virology,Immunology

Link

https://www.liebertpub.com/doi/pdf/10.1089/aid.2020.0097

Reference23 articles.

1. HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study

2. Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile

3. The Latent Human Immunodeficiency Virus (HIV) Reservoir Resides Primarily in CD32−CD4+ T Cells in Perinatally HIV-Infected Adolescents With Long-Term Virologic Suppression

4. Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication

5. HIV-1 viral rebound dynamics after a single treatment interruption depends on time of initiation of highly active antiretroviral therapy

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