Evaluating a Ligation-Mediated PCR and Pyrosequencing Method for the Detection of Clonal Contribution in Polyclonal Retrovirally Transduced Samples-Reference-Cited by-同舟云学术

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Evaluating a Ligation-Mediated PCR and Pyrosequencing Method for the Detection of Clonal Contribution in Polyclonal Retrovirally Transduced Samples

Published:2013-04 Issue:2 Volume:24 Page:68-79
ISSN:1946-6536
Container-title:Human Gene Therapy Methods
language:en
Short-container-title:Human Gene Therapy Methods

Author:

Brugman Martijn H.¹,Suerth Julia D.¹,Rothe Michael¹,Suerbaum Sebastian²,Schambach Axel¹,Modlich Ute¹,Kustikova Olga¹,Baum Christopher¹

Affiliation:

1. Institute of Experimental Hematology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.

2. Department of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.

Publisher

Mary Ann Liebert Inc

Subject

Genetics(clinical),Pharmacology,Genetics,Applied Microbiology and Biotechnology,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/hgtb.2012.175

Reference52 articles.

1. Basic local alignment search tool

2. Contributions of Gene Marking to Cell and Gene Therapies

3. Unique Integration Profiles in a Canine Model of Long-Term Repopulating Cells Transduced with Gammaretrovirus, Lentivirus, or Foamy Virus

4. Estimating abundances of retroviral insertion sites from DNA fragment length data

5. Integration profile of retroviral vector in gene therapy treated patients is cell‐specific according to gene expression and chromatin conformation of target cell

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1. A track of the clones: new developments in cellular barcoding;Experimental Hematology;2018-12

2. Non-Clinical Efficacy and Safety Studies on G1XCGD, a Lentiviral Vector for Ex Vivo Gene Therapy of X-Linked Chronic Granulomatous Disease;Human Gene Therapy Clinical Development;2018-06

3. Analyzing the Genotoxicity of Retroviral Vectors in Hematopoietic Cell Gene Therapy;Molecular Therapy - Methods & Clinical Development;2018-03

4. Integration Site Analysis in Gene Therapy Patients: Expectations and Reality;Human Gene Therapy;2017-12

5. Integrating Vectors for Gene Therapy and Clonal Tracking of Engineered Hematopoiesis;Hematology/Oncology Clinics of North America;2017-10

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