Design of a Phase I Clinical Trial to Evaluate Intratumoral Delivery of ErbB-Targeted Chimeric Antigen Receptor T-Cells in Locally Advanced or Recurrent Head and Neck Cancer-Reference-Cited by-同舟云学术

Design of a Phase I Clinical Trial to Evaluate Intratumoral Delivery of ErbB-Targeted Chimeric Antigen Receptor T-Cells in Locally Advanced or Recurrent Head and Neck Cancer

Published:2013-09 Issue:3 Volume:24 Page:134-142
ISSN:2324-8637
Container-title:Human Gene Therapy Clinical Development
language:en
Short-container-title:Human Gene Therapy Clinical Development

Author:

van Schalkwyk May C.I.¹,Papa Sophie E.¹,Jeannon Jean-Pierre²,Urbano Teresa Guerrero²,Spicer James F.¹,Maher John¹³⁴

Affiliation:

1. Department of Research Oncology, King's Health Partners Integrated Cancer Centre, King's College London, London SE1 9RT, United Kingdom.

2. Department of Head and Neck Oncology, Guy's and St. Thomas' NHS Foundation Trust, London SE1 9RT, United Kingdom.

3. Department of Immunology, Barnet and Chase Farm NHS Trust, Hertfordshire EN5 3DJ, United Kingdom.

4. Department of Clinical Immunology and Allergy, King's College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, United Kingdom.

Publisher

Mary Ann Liebert Inc

Subject

Genetics (clinical)

Link

http://www.liebertpub.com/doi/pdf/10.1089/humc.2013.144

Reference45 articles.

1. Adoptive transfer of autologous, HER2-specific, cytotoxic T lymphocytes for the treatment of HER2-overexpressing breast cancer

2. Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck

3. Phase III Randomized Trial of Cisplatin Plus Placebo Compared With Cisplatin Plus Cetuximab in Metastatic/Recurrent Head and Neck Cancer: An Eastern Cooperative Oncology Group Study

4. Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains

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