Update February 2021-Reference-Cited by-同舟云学术

Update February 2021

Published:2021-02-01 Issue:1 Volume:19 Page:96-109
ISSN:1539-6851
Container-title:Lymphatic Research and Biology
language:en
Short-container-title:Lymphatic Research and Biology

Author:

Blei Francine¹

Affiliation:

1. Lenox Hill Hospital, New York, New York, USA.

Publisher

Mary Ann Liebert Inc

Subject

Cardiology and Cardiovascular Medicine

Link

https://www.liebertpub.com/doi/pdf/10.1089/lrb.2021.29099.fb

Reference59 articles.

1. Update February 2021 Francine Blei, MD

2. Permana, A. D., et al. (2021). ``Recent advances in combination of microneedles and nanomedicines for Iymphatic targeted drug delivery.'' Wiley Interdiscip Rev Nanomed Nanobiotechnol: e1690. Numerous diseases have been reported to affect the lymphatic system. As such, several strategies have been developed to deliver chemotherapeutics to this specific network of tissues and associated organs. Nanotechnology has been exploited as one of the main approaches to improve the Iymphatic uptake of drugs. Different nanoparticle approaches utilized for both active and passive targeting of the Iymphatic system are discussed here. Specifically, due to the rich abundance of Iymphatic capillaries in the dermis, particular attention is given to this route of administration, as intradermal administration could potentially result in higher Iymphatic uptake compared to other routes of administration. Recently, progress in microneedle research has attracted particular attention as an alternative for the use of conventional hypodermic injections. The benefits of microneedles, when compared to intradermal injection, are subsequently highlighted. Importantly, microneedles exhibit particular benefit in relation to therapeutic targeting of the Iymphatic system, especially when combined with nanoparticles, which are further discussed. However, despite the apparent benefits provided by this combination approach, further comprehensive preclinical and clinical studies are now necessary to realize the potential extent of this dual-delivery platform, further taking into consideration eventual usability and acceptability in the intended patient end-users. This manuscript explores the potential of nanotechnology

3. Boehme, J. T., et al. (2021). ``HIF-1alpha promotes cellular

4. Cahill, T. J., et al. (2021). ``Tissue-resident macrophages regulate Iymphatic vessel growth and patterning in the developing heart.'' Development. E-Pub 2021/01/20 Macrophages are components of the innate immune system with key roles in tissue inflammation and repair. It is now evident that macrophages also support organogenesis, but few studies have characterized their identity, ontogeny and function during heart development. Here, we show that the distribution and prevalence of resident macrophages in the subepicardial compartment of the developing heart coincides with the emergence of new Iymphatics and macrophages interact closely with the nascent Iymphatic capillaries. Consequently, global macrophage-deficiency led to extensive vessel disruption with mutant hearts exhibiting shortened and mis-patterned Iymphatics. The origin of cardiac macrophages was linked to the yolk sac and fetal liver. Moreover, the Cx3cr1 (+) myeloid lineage was found to play essential functions in the remodeling of the Iymphatic endothelium. Mechanistically, macrophage hyaluronan was found to be required for Iymphatic sprouting by mediating direct macrophage-lymphatic endothelial cell interactions. Together, these findings reveal insight into the role of macrophages as indispensable mediators of Iymphatic growth during the development of the mammalian cardiac vasculature.

5. Fsp1 cardiac embryonic expression delineates atrioventricular endocardial cushion, coronary venous and lymphatic valve development

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