Higher Efficiency of Thymine–Adenine Clamp-Modified Single-Stranded Oligonucleotides in Targeted Nucleotide Sequence Correction Is Not Correlated with Lower Intracellular Degradation-Reference-Cited by-同舟云学术

Higher Efficiency of Thymine–Adenine Clamp-Modified Single-Stranded Oligonucleotides in Targeted Nucleotide Sequence Correction Is Not Correlated with Lower Intracellular Degradation

Published:2009-03 Issue:3 Volume:20 Page:283-287
ISSN:1043-0342
Container-title:Human Gene Therapy
language:en
Short-container-title:Human Gene Therapy

Author:

Wuepping M.¹,Kenner O.¹,Hegele H.¹,Schwandt S.¹,Kaufmann D.¹

Affiliation:

1. Institute of Human Genetics, University of Ulm, D 89070 Ulm, Germany.

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/hum.2008.138

Reference20 articles.

1. Stable transmission of targeted gene modification using single-stranded oligonucleotides with flanking LNAs

2. The DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts

3. Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice

4. Simultaneous targeted exchange of two nucleotides by single-stranded oligonucleotides clusters within a region of about fourteen nucleotides

5. Reaction Parameters of Targeted Gene Repair in Mammalian Cells

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