Individualized Antisense Oligonucleotide Therapies: How to Approach the Challenge of Manufacturing These Oligos from a Chemistry, Manufacturing, and Control-Regulatory Standpoint-Reference-Cited by-同舟云学术

Individualized Antisense Oligonucleotide Therapies: How to Approach the Challenge of Manufacturing These Oligos from a Chemistry, Manufacturing, and Control-Regulatory Standpoint

Published:2021-12-28 Issue: Volume: Page:
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Lemaitre Marc M.¹

Affiliation:

1. ML_Consult LLC, Cincinnati, Ohio, USA.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://www.liebertpub.com/doi/pdf/10.1089/nat.2021.0030

Reference12 articles.

1. Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease

2. The chemical evolution of oligonucleotide therapies of clinical utility

3. Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages

4. Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides

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1. A Guide to Chemical Considerations for the Pre-Clinical Development of Oligonucleotides;Nucleic Acid Therapeutics;2024-08-07

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