Phase I/II Study of Intrathecal Administration of Recombinant Human Hepatocyte Growth Factor in Patients with Acute Spinal Cord Injury: A Double-Blind, Randomized Clinical Trial of Safety and Efficacy-Reference-Cited by-同舟云学术

Phase I/II Study of Intrathecal Administration of Recombinant Human Hepatocyte Growth Factor in Patients with Acute Spinal Cord Injury: A Double-Blind, Randomized Clinical Trial of Safety and Efficacy

Published:2020-08-01 Issue:15 Volume:37 Page:1752-1758
ISSN:0897-7151
Container-title:Journal of Neurotrauma
language:en
Short-container-title:Journal of Neurotrauma

Author:

Nagoshi Narihito¹,Tsuji Osahiko¹,Kitamura Kazuya²,Suda Kota³,Maeda Takeshi⁴,Yato Yoshiyuki⁵,Abe Takayuki⁶⁷,Hayata Daichika⁸,Matsumoto Morio¹,Okano Hideyuki⁹,Nakamura Masaya¹

Affiliation:

1. Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan.

2. Department of Orthopedic Surgery, Saiseikai Yokohama-shi Tobu Hospital, Kanagawa, Japan.

3. Department of Orthopedic Surgery, Hokkaido Spinal Cord Injury Center, Hokkaido, Japan.

4. Department of Orthopedic Surgery, Spinal Injuries Center, Fukuoka, Japan.

5. Department of Orthopedic Surgery, Murayama Medical Center, National Hospital Organization, Tokyo, Japan.

6. Faculty of Data Science, Yokohama City University School of Data Science, Kanagawaken, Japan.

7. Biostatistics, Clinical and Translational Research Center, and Keio University School of Medicine, Tokyo, Japan.

8. Kringle Pharma, Inc., Osaka, Japan.

9. Department of Physiology, Keio University School of Medicine, Tokyo, Japan.

Publisher

Mary Ann Liebert Inc

Subject

Neurology (clinical)

Link

https://www.liebertpub.com/doi/pdf/10.1089/neu.2019.6854

Reference32 articles.

1. A Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury and Central Cord Syndrome: Recommendations on the Timing (≤24 Hours Versus >24 Hours) of Decompressive Surgery

2. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms

3. Cellular Delivery of Neurotrophin-3 Promotes Corticospinal Axonal Growth and Partial Functional Recovery after Spinal Cord Injury

4. Brain-Derived Neurotrophic Factor Stimulates Hindlimb Stepping and Sprouting of Cholinergic Fibers after Spinal Cord Injury

5. Nerve Growth Factor Delivery by Gene Transfer Induces Differential Outgrowth of Sensory, Motor, and Noradrenergic Neurites after Adult Spinal Cord Injury

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