Characterization of the Activity and Distribution of a 2′-O-Methoxyethyl-Modified Antisense Oligonucleotide in Models of Acute and Chronic Kidney Disease-Reference-Cited by-同舟云学术

Characterization of the Activity and Distribution of a 2′-O-Methoxyethyl-Modified Antisense Oligonucleotide in Models of Acute and Chronic Kidney Disease

Published:2018-10 Issue:5 Volume:28 Page:297-306
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Donner Aaron J.¹,Bell Thomas A.¹,Greenlee Sarah¹,Graham Mark J.¹,Crooke Rosanne M.¹

Affiliation:

1. Ionis Pharmaceuticals, Inc., Carlsbad, California.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://www.liebertpub.com/doi/pdf/10.1089/nat.2018.0723

Reference16 articles.

1. RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

2. Cross-Species Pharmacokinetic Comparison from Mouse to Man of a Second-Generation Antisense Oligonucleotide, ISIS 301012, Targeting Human Apolipoprotein B-100

3. Renal uptake of an 18-mer phosphorothioate oligonucleotide

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