Application of 2′-O-(2-N-Methylcarbamoylethyl) Nucleotides in RNase H-Dependent Antisense Oligonucleotides-Reference-Cited by-同舟云学术

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Application of 2′-O-(2-N-Methylcarbamoylethyl) Nucleotides in RNase H-Dependent Antisense Oligonucleotides

Published:2018-10 Issue:5 Volume:28 Page:307-311
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Masaki Yoshiaki¹,Iriyama Yusuke²,Nakajima Hiroyuki³,Kuroda Yusuke³,Kanaki Tatsuro³,Furukawa Satoshi³,Sekine Mitsuo¹,Seio Kohji¹

Affiliation:

1. Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.

2. Nissan Chemical Corporation, Chemical Research Laboratories, Funabashi, Japan.

3. Nissan Chemical Corporation, Biological Research Laboratories, Shiraoka, Japan.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://www.liebertpub.com/doi/pdf/10.1089/nat.2018.0738

Reference16 articles.

1. The chemical evolution of oligonucleotide therapies of clinical utility

2. Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

3. Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals

4. Antisense Oligonucleotides Containing Conformationally Constrained 2′,4′-(N-Methoxy)aminomethylene and 2′,4′-Aminooxymethylene and 2′-O,4′-C-Aminomethylene Bridged Nucleoside Analogues Show Improved Potency in Animal Models

5. Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

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1. Synthesis and Evaluation of 4′‐C‐(S) and 4′‐C‐(R)‐2‐Aminopropoxy−Thymidine‐Modified DNAs for Thermal Stability, RNase H Digestion, and Nuclease Resistance;ChemistrySelect;2024-06-18

2. Improving DNA nanostructure stability: A review of the biomedical applications and approaches;International Journal of Biological Macromolecules;2024-03

3. Nucleic acid degradation as barrier to gene delivery: a guide to understand and overcome nuclease activity;Chemical Society Reviews;2024

4. New Oligonucleotide 2′-O-Alkyl N3′→P5′ (Thio)-Phosphoramidates as Potent Antisense Agents: Physicochemical Properties and Biological Activity;Nucleic Acid Therapeutics;2023-10-01

5. Synthesis of 2′-O-[3-(N-methylsulfamoyl)propan-1-yl]ribothymidine as a potentially applicable 2′-modified nucleoside for antisense oligonucleotides;Bioorganic & Medicinal Chemistry;2022-11

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