Chemical Modification Study of Antisense Gapmers-Reference-Cited by-同舟云学术

Chemical Modification Study of Antisense Gapmers

Published:2012-10 Issue:5 Volume:22 Page:344-359
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Stanton Robert¹,Sciabola Simone¹,Salatto Christopher²,Weng Yan³,Moshinsky Debra¹,Little Jeremy¹,Walters Evan¹,Kreeger John⁴,DiMattia Debra²,Chen Tracy¹,Clark Tracey³,Liu Mei¹,Qian Jessie⁴,Roy Marc⁴,Dullea Robert²

Affiliation:

1. Oligonucleotide Therapeutic Unit, Pfizer, Cambridge, Massachusetts.

2. Cardiovascular and Metabolic Disease, Pfizer, Cambridge, Massachusetts.

3. Pharmacokinetics, Dynamics and Metabolism, Pfizer, Groton, Connecticut.

4. Safety Science, Pfizer, Groton, Connecticut.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry

Link

http://www.liebertpub.com/doi/pdf/10.1089/nat.2012.0366

Reference55 articles.

1. Effect of Mipomersen, an Apolipoprotein B Synthesis Inhibitor, on Low-Density Lipoprotein Cholesterol in Patients With Familial Hypercholesterolemia

2. Chemical Modification of Oligonucleotides for Therapeutic, Bioanalytical and other Applications

3. Binding, uptake, and intracellular trafficking of phosphorothioate-modified oligodeoxynucleotides.

4. RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

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