Non-Clinical Safety Studies of IMT504, a Unique Non-CpG Oligonucleotide-Reference-Cited by-同舟云学术

Non-Clinical Safety Studies of IMT504, a Unique Non-CpG Oligonucleotide

Published:2014-08 Issue:4 Volume:24 Page:267-282
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Franco Raúl¹,Rodriguez Juan M.²,Elías Fernanda¹,Hernando-Insúa Andrés²,Fló Juan¹,López Ricardo¹,Nagle Carlos³,Lago Néstor⁴,Zorzopulos Jorge¹,Horn David L.⁵,Montaner Alejandro D.⁶

Affiliation:

1. Immunotech S.A., Ciudad de Buenos Aires, Argentina.

2. Fundación Pablo Cassará, Ciudad de Buenos Aires. Argentina.

3. Centro de Educación Médica e Investigaciones Clínicas (CEMIC), Ciudad de Buenos Aires. Argentina.

4. Departamento de Patología. Facultad de Medicina. Universidad de Buenos Aires Ciudad de Buenos Aires, Argentina.

5. David Horn LLC, Doylestown, Pennsylvania.

6. Instituto de Ciencia y Tecnología “Dr. Cesar Milstein,” Ciudad de Buenos Aires, Argentina.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry

Link

http://www.liebertpub.com/doi/pdf/10.1089/nat.2013.0479

Reference39 articles.

1. Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.

2. Oligodeoxynucleotide IMT504 induces a marked recovery in a streptozotocin-induced model of diabetes in rats: correlation with an early increase in the expression of nestin and neurogenin 3 progenitor cell markers

3. CpG DNA as a vaccine adjuvant

4. Oligonucleotide IMT504 reduces neuropathic pain after peripheral nerve injury

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1. Mesenchymal Stem Cell Engagement Modulates Neuroma Microenviroment in Rats and Humans and Prevents Postamputation Pain;The Journal of Pain;2024-08

2. Oligodeoxynucleotide IMT504: Effects on Central Nervous System Repair Following Demyelination;Molecular Neurobiology;2023-12-08

3. IMT504 protects beta cells against apoptosis and maintains beta cell identity, without modifying proliferation;Physiological Reports;2023-08

4. Modulation of the Inflammatory Response by Pre-emptive Administration of IMT504 Reduces Postoperative Pain in Rats and has Opioid-Sparing Effects;The Journal of Pain;2023-06

5. IMT504 blocks allodynia in rats with spared nerve injury by promoting the migration of mesenchymal stem cells and by favoring an anti-inflammatory milieu at the injured nerve;Pain;2021-09-15