Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme-Reference-Cited by-同舟云学术

Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme

Published:2020-01-01 Issue:1 Volume:32 Page:1-17
ISSN:1523-0864
Container-title:Antioxidants & Redox Signaling
language:en
Short-container-title:Antioxidants & Redox Signaling

Author:

Marbach-Breitrück Eugenia¹,Kutzner Laura²,Rothe Michael³,Gurke Robert⁴⁵,Schreiber Yannick⁵,Reddanna Pallu⁶,Schebb Nils-Helge²,Stehling Sabine¹,Wieler Lothar H.⁷⁸,Heydeck Dagmar¹,Kuhn Hartmut¹

Affiliation:

1. Institute of Biochemistry, Charité—University Medicine Berlin, Corporate Member of Free University Berlin, Humboldt-University zu Berlin, Berlin Institute of Health, Berlin, Germany.

2. Faculty of Mathematics and Natural Sciences, University of Wuppertal, Wuppertal, Germany.

3. Lipidomix GmbH, Berlin, Germany.

4. Pharmazentrum Frankfurt (ZAFES), Institute of Clinical Pharmacology, Goethe University, Frankfurt am Main, Germany.

5. Branch for Translational Medicine and Pharmacology (TMP), Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Frankfurt am Main, Germany.

6. Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad India.

7. Robert Koch Institute, Berlin, Germany.

8. Institute of Microbiology and Epizootics, Center of Infection Medicine, Free University of Berlin, Berlin, Germany.

Publisher

Mary Ann Liebert Inc

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,Physiology,Biochemistry,Cell Biology,Clinical Biochemistry,Molecular Biology,Physiology,Biochemistry

Link

https://www.liebertpub.com/doi/pdf/10.1089/ars.2019.7751

Reference77 articles.

1. The double-edged role of 12/15-lipoxygenase during inflammation and immunity

2. The lipoxygenase pathway in zebrafish. Expression and characterization of zebrafish ALOX5 and comparison with its human ortholog

3. Phosphorylation mimicking mutations of ALOX5 orthologs of different vertebrates do not alter reaction specificities of the enzymes

4. Leukotriene signaling in the extinct human subspecies Homo denisovan and Homo neanderthalensis. Structural and functional comparison with Homo sapiens

5. Fat poetry: a kingdom for PPARγ

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