AAV5 Delivery of CRISPR/Cas9 Mediates Genome Editing in the Lungs of Young Rhesus Monkeys

Author:

Liang Shun-Qing1,Navia Andrew W.234,Ramseier Michelle234,Zhou Xuntao1,Martinez Michele5,Lee Charles5,Zhou Chen67,Wu Joae8,Xie Jun679ORCID,Su Qin679,Wang Dan67ORCID,Flotte Terence R.6,Anderson Daniel G.10111213,Tarantal Alice F.5,Shalek Alex K.234,Gao Guangping679,Xue Wen17ORCID

Affiliation:

1. RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts, USA

2. Institute for Medical Engineering and Science, Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

3. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA

4. Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA

5. Departments of Pediatrics and Cell Biology and Human Anatomy, School of Medicine, and California National Primate Research Center, University of California, Davis, California, USA

6. Horae Gene Therapy Center and Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA

7. Li Weibo Institute for Rare Diseases Research, University of Massachusetts Medical School, Worcester, Massachusetts, USA

8. Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA

9. Viral Vector Core, University of Massachusetts Medical School, Worcester, Massachusetts, USA

10. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

11. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

12. Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;

13. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

Publisher

Mary Ann Liebert Inc

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