Determination of in Vitro Antioxidant, Antimicrobial Properties and COX-1/COX-2 Enzyme Inhibition Activity of Capparis Sicula
Author:
ACAR Nağihan1ORCID, ÇELİKEZEN Fatih Çağlar2ORCID, ŞAHİN İbrahim Halil1ORCID, FIRAT Mehmet3ORCID, KOÇYİĞİT Recep1ORCID, KİREÇCİ Oğuz Ayhan1ORCID
Affiliation:
1. BİTLİS EREN ÜNİVERSİTESİ 2. BITLIS EREN UNIVERSITY 3. VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ
Abstract
Since synthetic drugs cause many side effects and have a high cost, there has been increasing interest in the development of herbal-based drugs that have fewer side effects and are relatively inexpensive. Capparis sicula is traditionally used in the treatment of some diseases among people. For this purpose, the antioxidant and antimicrobial properties of the methanol extract of the Capparis sicula plant and its inhibitory effects on COX-1 and COX-2 enzymes were investigated. In the study, the antioxidant properties of the Capparis sicula plant were determined by DPPH and CUPRAC methods, while its antimicrobial properties were determined by the disk diffusion method. The effect of Capparis sicula on COX-1 and COX-2 enzymes was determined colorimetrically using commercial kits. The results showed that Capparis sicula had a significant antioxidant effect, but did not have any antimicrobial effect on standard strains of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans. In addition, the inhibitory effect on the COX-1 enzyme was 4.23% for the first time, and the inhibition effect on the COX-2 enzyme was determined as 23.21%. As a result, the pharmaceutical, food and cosmetic industries can use Capparis sicula as an important source of natural raw materials.
Funder
Bitlis Eren Üniversitesi BAP
Publisher
KSU Journal of Agriculture and Nature
Subject
General Earth and Planetary Sciences,General Engineering,General Environmental Science
Reference70 articles.
1. Abbas, J.A., El-Oglah, A.A. & Mahasneh, A.M. (1992). Herbal plants in the traditionalmedicine of Bahrain. Econ Bot, 46, 158-163. 2. Abdu-Allah, H.H., Abdelmoez, A.A., Tarazi, H., El-Shorbagi, ANA. & El-Awady, R. (2020). Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids. Bioorg Chem, 94, 103378 3. Abdu-Allah, H.H., Abdelmoez, A.A., Tarazi, H., El-Shorbagi, ANA. & El-Awady, R. (2020). Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids. Bioorg Chem, 94, 103378 4. Ageel, A.M., Parmar, N.S., Mossa, J.S., Yahya, M.A.A., Said, M.S.A. & Tariq, M. (1986). Anti-inflammatory activity of some Saudi Arabian medicinal plants. Agents Action, 17, 383-384. 5. Ageel, A.M., Parmar, N.S., Mossa, J.S., Yahya, M.A.A., Said, M.S.A. & Tariq, M. (1986). Anti-inflammatory activity of some Saudi Arabian medicinal plants. Agents Action, 17, 383-384.
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