The effects of omega-3 fatty acids on antioxidant enzyme activities and nitric oxide levels in the cerebral cortex of rats treated ethanol-Reference-Cited by-同舟云学术

The effects of omega-3 fatty acids on antioxidant enzyme activities and nitric oxide levels in the cerebral cortex of rats treated ethanol

Published:2024 Issue:2 Volume:70 Page:83-88
ISSN:2310-6905
Container-title:Biomeditsinskaya Khimiya
language:ru
Short-container-title:BIOMED KHIM

Author:

Oktar Süleyman¹,Karadeniz Mahinur²,Acar Musa³,Zararsız İsmail⁴

Affiliation:

1. University of Health Sciences, Beyhekim Training and Research Hospital, Department of Pharmacology, Konya, Turkey

2. Selçuklu District Health Directorate, Selçuklu, Konya, Turkey

3. Necmettin Erbakan University, Faculty of Health Sciences, Department of Physical Therapy and Rehabilitation, Konya, Turkey

4. Girne American University, Medical Faculty, Department of Anatomy, Girne, Cyprus

Abstract

The toxic effect of ethanol on the cerebral cortex and protective effects of omega-3 fatty acids against this neurotoxicity were investigated. Twenty eight male Wistar-albino rats were divided into 4 groups. Rats of the ethanol and ethanol withdrawal groups were treated with ethanol (6 g/kg/day) for 15 days. Animals of the ethanol+omega-3 group received omega-3 fatty acids (400 mg/kg daily) and ethanol. In rats of the ethanol group SOD activity was lower than in animals of the control group. In rats treated with omega-3 fatty acids along with ethanol SOD, activity increased. GSH-Px activity and MDA levels in animals of all groups were similar. In ethanol treated rats NO levels significantly decreased as compared to the animals of the control group (6.45±0.24 nmol/g vs 11.05±0.53 nmol/g, p

Publisher

Institute of Biochemistry

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