Perspective non-invasive biomarkers: intestinal proteins in the diagnosis for diagnosis and control of intestinal mucosal damage-Reference-Cited by-同舟云学术

Perspective non-invasive biomarkers: intestinal proteins in the diagnosis for diagnosis and control of intestinal mucosal damage

Published:2021-07-21 Issue:4 Volume: Page:155-160
ISSN:1682-8658
Container-title:Experimental and Clinical Gastroenterology
language:
Short-container-title:jour

Author:

Khavkin A. I.¹^ORCID,Novikova V. P.²^ORCID,Shapovalova N. S.²^ORCID

Affiliation:

1. N. I. Pirogov Russian National Research Medical University

2. St. Petersburg State Pediatric Medical University

Abstract

The aim of this literature review was to consider the diagnostic value of potential biomarkers detection: citrulline and intestinal proteins, designed to detect intestinal mucosa damage.Conclusion: determination of I-FABP and I-BABP in blood are promising methods for non-invasive diagnosis of the intestinal damage, since these proteins are released from the damaged enterocytes. However, the determination of intestinal proteins is important in combination with the determination of citrulline. Several studies have shown that citrulline can be measured in animal models, in adult and pediatric patients. It is easily detectable, consistently measured and capable of detecting inflammation of the intestinal mucosa. The limitation of most studies was the small sample size. Non-invasive diagnostic and therapeutic monitoring techniques remain an important area of further research.

Publisher

LLC Global Media Technology

Subject

Gastroenterology,Hepatology

Reference45 articles.

1. Belmer S.V., Razumovsky A. Yu., Khavkin A. I., et al. Bolezni kishechnika u detej [Bowel diseases in children]. Medpractica- M. 2018. Volume 1. 436 p. (In Russ.)

2. Belmer S.V., Razumovsky A. Yu., Khavkin A. I., et al. Bolezni kishechnika u detej [Bowel diseases in children]. Medpractica- M. 2018. Volume 2. 496 p. (In Russ.)

3. Kalinina E. Yu., Anichkov N. M. Celiac disease in adults: histological and morphometric data. Archive of pathology. 2005. Vol. 67, no. 2, pp. 33–38. (In Russ.)

4. Kalinina E. Yu., Anichkov N. M., Krylova Yu., Novikova V. P. Nejroendokrinnye diff erony pri duodenitah razlichnoj etiologii u detej [Neuroendocrine differons for duodenitis of various etiology in children]. Voprosy detskoj dietologii [Questions of children’s dietetics]. 2017;15(2): 49–50. (In Russ.)

5. Metody issledovaniya organov pishchevareniya. Gastroenterologiya: rukovodstvo dlya vrachej pod redakciej E. I. Tkachenko [Methods of research of the digestive system. Gastroenterology: a guide for doctors edited by E. I. Tkachenko]. Publishing house Spets- Lit, 2013, pp. 16–83. (In Russ.)

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. When is it possible to get false positive screening results for celiac disease?;Experimental and Clinical Gastroenterology;2023-05-21