Systematic analysis of the experimental and clinical pharmacology of nicotinamide and prospects for the treatment of atherosclerosis-Reference-Cited by-同舟云学术

Systematic analysis of the experimental and clinical pharmacology of nicotinamide and prospects for the treatment of atherosclerosis

Published:2023-01-18 Issue:10 Volume: Page:111-125
ISSN:1682-8658
Container-title:Experimental and Clinical Gastroenterology
language:
Short-container-title:jour

Author:

Gromova O. A.¹^ORCID,Torshin I. Yu.¹^ORCID

Affiliation:

1. Federal Research Center “Computer Science and Control” of the Russian Academy of Sciences

Abstract

Nicotinamide (niacin) is a PP (Pellagra-Preventive) vitamer necessary for the synthesis of nicotinamide adenine dinucleotide (NAD). The NAD molecule is a coenzyme of proteins involved in the synthesis of ATP from fats and carbohydrates. For more than 50 years, nicotinamide has been used as an antihyperlipidemic agent and to improve blood microcirculation. The results of a systematic analysis of 70417 publications on the pharmacology of nicotinamide made it possible to clarify the molecular mechanisms of the vasoprotective action of nicotinamide (including anti-inflammatory action), to summarize the results of experimental and clinical studies of anti-atherosclerotic effects (including the treatment of steatohepatosis and counteraction to obesity) and the cardioprotective properties of nicotinamide. The prospects for the combined use of statins and nicotinamide are shown, which allows to reduce the dosage of statins.

Publisher

LLC Global Media Technology

Subject

Gastroenterology,Hepatology

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