Free-radical liver damage correction in mechanical jaundice

Abstract

Objectives: The aim of this study was to evaluate the hepatoprotective activity of resveratrol in patients with morphofunctional liver disorders due to mechanical jaundice. Methods: The controlled mechanical jaundice was simulated on the rats under anesthesia by drainage of the choledochus and its plugging. In the control group decompression of the choledochus was performed on the 3rd day and intravenous infusion of 0,9% sodium chloride solution was administrated for 12 days. In the experimental group after billiar decompression, resveratrol was administered intravenously at a dose of 20 mg/kg. The following were studied: level of malondialdehyde, catalase, bilirubin, alanine aminotransferase (ALAT), aspartate aminotransferase; liver histology was performed. Results: Catalase was 3.9 times reliably increased, and the activity of malonic dialdehyde and ALAT was 2.0 and 3.6 times reliably decreased in experimental group compared to the control group. Microscopic shows edema and destruction of the liver were reduced, the architectonic of the liver lobules was recovered. Conclusion: Application of resveratrol in mechanical jaundice decreased the processes of free-radical oxidation and level of the liver cells cytolysis markers which morphologically was shown by edema reduction, restoration of the liver lobules structure.